Abstract
Introduction: Neurofibroma of the nasal septum is a rare benign tumor with non-specific clinical and radiological features, frequently mimicking malignant lesions (e.g., chondroma or sarcoma) and leading to diagnostic uncertainty. This poses significant challenges in preoperative planning and surgical approach selection.
Case presentation: A 63-year-old woman presented with chronic nasal obstruction. Imaging suggested chondroma or sarcoma. Complete endoscopic resection led to a diagnosis of neurofibroma (PS100+, CD34-). The postoperative course was favorable, with no recurrence after 22 months of follow-up.
Conclusion: This case underscores the diagnostic dilemma of solitary nasal neurofibromas and demonstrates that transnasal endoscopic resection is an effective solution, ensuring complete excision while preserving function and aesthetics.
Keywords: nasal neoplasm, neurofibroma, endoscopic surgery
